Charged particles (ions) range from lighter electrons and positrons to heavier alpha particle and other not neutral nuclei. The charge is measured in coulomb.

An accelerator uses electrostatic or electromagnetic fields to increase the kinetic energy of charged particles (see alpha particle, beta particle) in order to produce ionization or a nuclear reaction in a target.
Accelerators (see cyclotron, linear accelerator) are used for the production of radionuclides (see Fluorine-18, Molybdenum, Technetium-99m) or directly for radiation therapy. Accelerator-produced radioactive material (ARM) is any radioactive substance that is produced by a particle accelerator. The accelerators used for radiation therapy generate gamma rays (also called Bremsstrahlung) with continuous energy by collision of high energy electrons on materials with high density (also referred as 'high z' - chemical elements with a high atomic number (Z)).
Electron accelerators with energies above 10 MeV can also produce neutrons induced by photons in the accelerator head material (mainly caused by photo nuclear reaction).

In cyclotrons charged particles are circular accelerated to bombard atoms. Short-lived positron-emitting isotopes are produced for Positron Emission Tomography (PET) imaging (e.g. F-18).

See also Linear Accelerator, Metastable Condition, Meson, Fluorodeoxyglucose, Electric Polarization.

Ionization is the process of converting an atom or molecule with no electrical charge into an ion by adding or removing charged particles such as electrons or other ions, through high temperatures, electrical discharges, radiation etc.

See also Ion.

Nonionic contrast agents are a group of contrast media that do not dissociate into charged particles. Many of the side effects of contrast agents are due to the injection of a solution with high osmolality compared to blood. Nonionic contrast agents have a low osmolality and tend to have less toxicity. However, as with all iodinated contrast agents, serious or fatal reactions have been associated with their use.
Due to their lower neurotoxicity, nonionic contrast agents can also be used for myelography. The only FDA approved agent, iodixanol, is iso-osmolar to blood, which makes it preferable for examinations of the central nervous system and cardiovascular studies. Because of its higher costs relative to other nonionic agents, the use is sometimes reserved for patients with high risk of nephrotoxicity.

See also Nonionic Dimer, Nonionic Monomer and CM Ratio.