(MIRD) The medical internal radiation dose committee is the society of nuclear medicine responsible for the internal dosimetry of diagnostic imaging radiopharmaceuticals.

(MPI) The myocardial perfusion scan is the most common nuclear medicine procedure in cardiac imaging and allows assessing the blood-flow patterns to the heart muscles. The comparison of the radiopharmaceutical distribution after stress and at rest provides information on myocardial viability and cardiac perfusion abnormalities. ECG-gated myocardial perfusion imaging allows the assessment of global and regional myocardial function such as wall motion abnormalities.
The diagnostic accuracy of myocardial perfusion scintigraphy (also abbreviated MPS) allows reliable risk stratification and guides the selection of patients for further interventions, such as revascularization. MPI also has particular advantages over alternative techniques in the management of a number of patient subgroups, including women, the elderly, and those with diabetes. The use of this type of cardiac scintigraphy is associated with greater cost effectiveness of treatment, in terms of life-years saved, particularly in these special patient groups.
Myocardial perfusion scintigrams are acquired with a gamma camera. Single photon emission computed tomography (SPECT) is preferred over planar imaging because of the three dimensional nature of the images and their superior contrast resolution.
Common MPI radiopharmaceuticals, approved by the U.S. Food and Drug Administration (FDA) include: Tl-201 and the Tc-99m-labeled radiopharmaceuticals, such as sestamibi, tetrofosmin, and teboroxime for single-photon imaging. Rb-82 is used for positron emission tomography (PET) imaging.

See also Gated Blood Pool Scintigraphy, Myocardial Late Enhancement, Cardiac MRI and Echocardiography.

(Osm) A unit of osmotic pressure used in physical chemistry, cell biology, and medicine.
Definition: 1 osmole is the osmotic pressure of a one molar solution (that is, a solution with a concentration of one mole per liter of solvent) of a substance that does not dissociate.
If chemical solutions are separated by a semipermeable membrane (a membrane that resists the passage of dissolved substances but permits the passage of the solvent, usually water), then the solvent will diffuse across the membrane to equalize the concentrations. This process is called osmosis.
Solutions with higher concentrations of dissolved substances are said to have higher osmotic pressure than solutions having lower concentrations; thus the solvent moves from an area of low osmotic pressure to an area of higher osmotic pressure.
Osmotic pressure depends on the total number of dissolved particles, so for a substance that dissociates into two ions, such as ordinary salt (sodium chloride), a one molar solution has an osmotic pressure of 2 osmoles. In practice, most measurements are in milliosmoles (mOsm). Typical values range from 20 mOsm for fresh water through 290 mOsm for typical human blood plasma to 1010 mOsm for salt water from the open ocean.
See also Part Per Million.

(PACS) Picture Archiving and Communication System is an IT-based storage and retrieval system for digital images.

See also Radiology Information System and Digital Imaging And Communications In Medicine.

Radiation safety concerns the safe use of ionizing radiation. The radiation exposure has to be controlled to protect people and the environment from unnecessary exposure and the damaging effect to the health. Legal regulations require that radiation exposure (individual radiation exposure as well as collective dose) must be kept as low as reasonably achievable.
The electromagnetic spectrum includes x-rays, gamma rays, ultraviolet radiation, visible light, infrared radiation, and radio waves. Additionally, there are several types of particulate radiation e.g., alpha and beta particles. All types of radiation are used in a wide range of medicine, industry, research and communication. Radiation risks can occur due to either long-term low level exposure or short-term high level exposure. A well-functioning dosimetry program is essential for a safe use and for compliance with federal and state regulations.

Three basic rules have to be observed for a safe use of ionizing radiation.

See also Inverse Square Law, Administrative Dose Guidelines and Annual Dose Limit.