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| | | | Result : Searchterm 'Contrast Enhancement' found in 1 term [ ] and 6 definitions [ ], (+ 3 Boolean[ ] results
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Hypaque™ meglumine is an ionic contrast agent. Hypaque™ meglumine 60 percent (w/v) is an aqueous solution containing 60 g of the meglumine salt of diatrizoic acid per 100 mL of solution.
The degree of contrast enhancement at computed tomography is directly related to the amount of iodine administered. In adults the amount of iodine usually required for contrast enhancement ranges from 28 to 42 g.
Hypaque™ meglumine is also available in concentrations of 18% and 30%.
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Drug Information and Specification |
| NAME OF COMPOUND |
Diatrizoate meglumine |
| MANUFACTURER |
GE Healthcare |
| INDICATION |
Urography, angiography, CT head |
| APPLICATION |
Intravascular |
| PHARMACOKINETIC |
Renal excretion |
| CHEMICAL BOND |
Ionic monomer |
| OSMOLALITY |
1415 mosm/kgH2O |
| IODINE CONCENTRATION |
282 mg/mL |
| DOSAGE |
50 - 100 mL bolus injection, up to 150 mL by infusion |
| PREPARATION |
Ready-to-use product |
| STORAGE |
Protect from light. Store at 15°Celsius to 30°C (59° Fahrenheit to 86°F). |
| PRESENTATION |
50 and 100 mL vials, 200 mL bottles |
| DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING
PACKAGE INSERT! |
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(CTA) A computed tomographic angiography or computerized tomography angiogram is a diagnostic imaging test that combines conventional CT technique with that of traditional angiography to create images of the blood vessels in the body - from brain vessels to arteries of the lungs, kidneys, arms and legs.
High resolution CT scans with thin slices and intravenous injection of iodinated contrast material provide detailed images of vascular anatomy and the adjacent bony structures. CTA requires rapid scanning as the imaging data are typically acquired during the first pass of a bolus of contrast medium. The selection of acquisition timing is important to optimize the contrast enhancement, which is dependent on contrast injection methods, imaging techniques and patient variations in weight, age and health. CT angiography is less invasive compared to conventional angiography and the data can be rendered in three dimensions.
CTA techniques are commonly used to:
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Detect pulmonary embolism with computed tomography pulmonary angiography; |
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rule out coronary artery disease with coronary CT angiography; |
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evaluate heart disease with cardiac CT; |
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identify aneurysms, dissections, narrowing, obstruction and other vessel disease in the aorta or major blood vessels; |
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See also Cardiovascular Imaging, Magnetic Resonance Angiography MRA, Coronary Angiogram, Computed Tomography Dose Index and Computed or Computerized Axial Tomography.
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| | | | | | (CA) Contrast agents are used to change the imaging characteristics, resulting in additional information about anatomy, morphology or physiology of the human body. Radiocontrast agents (also called photon-based imaging agents) are used to improve the visibility of internal body structures in x-ray and CT procedures. Contrast agents are also used to increase the contrast between different tissues in MRI (magnetic resonance imaging) and ultrasound imaging. The ideal imaging agent provides enhanced contrast with little biological interaction.
First investigations with radiopaque materials are done shortly after the discovery of x-rays. These positive contrast agents attenuate x-rays more than body soft tissues due to their high atomic weight. Iodine and barium have been identified as suitable materials with high radiodensity and are used until today in x-ray and CT contrast agents. Iodine-based contrast agents are water-soluble and the solutions are used nearly anywhere in the body. Iodinated contrast materials are most administered intravenous, but can also be introduced intraarterial, intrathecal, oral, rectal, intravesical, or installed in body cavities. Barium sulfate is only used for opacification of the gastrointestinal tract. Negative contrast agents attenuate x-rays less than body soft tissues, for example gas.
Iodinated contrast media are differentiated in:
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Intravascular iodinated contrast agents are required for a large number of x-ray and CT studies to enhance vessels and organs dependent on the blood supply. Injectable contrast agents are diluted in the bloodstream and rapidly distributed throughout the extracellular fluid. The main route of excretion is through the kidneys, related to the poor binding of the agent to serum albumin. The liver (gall bladder) and small intestine provide alternate routes of elimination particularly in patients with severe renal impairment. The use of special biliary contrast agents is suitable for gallbladder CT and cholecystograms because they are concentrated by the liver to be detectable in the hepatic bile.
The introduction of fast multi-detector row CT technology, has led to the development of optimized contrast injection techniques. The amount of contrast enhancement depends on the contrast agent characteristics, such as iodine concentration, osmolality, viscosity, and the injection protocol, such as iodine flux and iodine dose. Adverse reactions are rare and have decreased with the introduction of nonionic contrast agents.
See also Contrast Enhanced Computed Tomography and Abdomen CT.
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| | | •• There are 4 news about 'Contrast Agents'. | |
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| | | | Contrast Enhanced Computed Tomography | |
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(CECT) Contrast agents are used during contrast enhanced computed (or computerized) tomography examinations to highlight specific tissues and parts of the body. Bones can be clearly seen on x-ray images, the visualization of some other organs and soft tissues is more difficult. Sufficient contrast is important in perceiving a difference in the density between areas of a CT image. The identification of a disease may be challenging due to very low contrast between pathological tissues (for example tumors, metastases and abscesses), normal organ structures and surrounding tissues.
Contrast agents are used in CT angiography (CTA) to delineate vessels, in multiphasic CT studies to provide dynamic information of blood supply (e.g., liver CT) and in CECT studies of various body parts to achieve opacification of tissue of interest (e.g., kidney CT) in relation to the background tissue.
Contrast enhanced multi-detector row CT (MDCT) replaces several conventional diagnostic imaging methods such as intravenous urography, cholangiography, or catheter angiography, due to advanced CT studies with fast examination times, high contrast enhancement, perfusion measurement and multiplanar reformatting capabilities.
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| | | | Further Reading: | | Basics: | | | News & More: |  | | | | MANUAL ON CONTRAST MEDIA | | 'Version 6 of the Manual on Contrast Media was published in May, 2008 as a web-based product. Content changes may take place as a ...' | | May 2008 by www.acr.org |
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