(LOCM) Low-osmolar contrast media have a wide range of indications due to their lower side effects. The type of contrast media is an important risk factor for an adverse reaction.
LOCM have not completely replaced contrast media with higher osmolality due to their higher cost. Guidelines of professional organizations give recommendations for the selective use of low-osmolar contrast media for certain high-risk patients.
There are ionic and nonionic iodinated contrast materials with low osmolality available:
An adverse reaction occurs in low-risk patients who receive conventional ionic contrast agents more often than in high-risk patients who receive nonionic LOCM.

See also Contrast Enhancement, Biliary Contrast Agents, Safety of Contrast Agents and Contrast-Induced Nephropathy.

Oxilan® is a radiographic contrast agent used in diagnostic imaging studies. The degree of contrast enhancement is directly related to the iodine content in the administered dose. Dependent on the iodine content, the osmolalities are 2.1 or 2.4 times that of plasma (285 mOsm/kg water).

(CTE) Computed tomography enterography is an imaging procedure to evaluate diseases affecting the mucosa and bowel wall of the small intestine. CTE uses oral contrast agents to improve bowel wall visualization. Several studies established that small bowel distention using negative oral contrast agent increases diagnostic performance of some abdomen CT studies.
The multi-detector row CT (MDCT) improves temporal and spatial resolution and 3D imaging processes offer a full examination of the small bowel with surrounding structures, depicting the small bowel inflammation associated with Crohn's disease by displaying mural hyperenhancement, stratification, and thickening.
CT enterography versus capsule endoscopy provides a non invasive study with comparable sensitivity, high specificity and overall accuracy.

See also Colonoscopy and Virtual Colonoscopy.

(MPI) The myocardial perfusion scan is the most common nuclear medicine procedure in cardiac imaging and allows assessing the blood-flow patterns to the heart muscles. The comparison of the radiopharmaceutical distribution after stress and at rest provides information on myocardial viability and cardiac perfusion abnormalities. ECG-gated myocardial perfusion imaging allows the assessment of global and regional myocardial function such as wall motion abnormalities.
The diagnostic accuracy of myocardial perfusion scintigraphy (also abbreviated MPS) allows reliable risk stratification and guides the selection of patients for further interventions, such as revascularization. MPI also has particular advantages over alternative techniques in the management of a number of patient subgroups, including women, the elderly, and those with diabetes. The use of this type of cardiac scintigraphy is associated with greater cost effectiveness of treatment, in terms of life-years saved, particularly in these special patient groups.
Myocardial perfusion scintigrams are acquired with a gamma camera. Single photon emission computed tomography (SPECT) is preferred over planar imaging because of the three dimensional nature of the images and their superior contrast resolution.
Common MPI radiopharmaceuticals, approved by the U.S. Food and Drug Administration (FDA) include: Tl-201 and the Tc-99m-labeled radiopharmaceuticals, such as sestamibi, tetrofosmin, and teboroxime for single-photon imaging. Rb-82 is used for positron emission tomography (PET) imaging.

See also Gated Blood Pool Scintigraphy, Myocardial Late Enhancement, Cardiac MRI and Echocardiography.

The digital mammography is an electronic imaging procedure of the breast. The number of breast imaging facilities equipped with digital mammography (also called computed radiography mammogram (CRM), CR mammogram) is growing due to a number of advantages.
Digital images can be stored directly in a picture archiving and communication system (PACS) and allows the printing, enhancement, magnification, or brightness and contrast manipulation for further evaluation. The sensitivity of digital mammography compared to film mammography is better in women with dense breasts, a population at higher risk for breast cancer, due to these post processing possibilities.
'The American College of Radiology's (ACR) Imaging Network found that digital mammography detected up to 28 percent more cancers than film-screen mammography in women age 50 and younger, premenopausal and perimenopausal women, and women with dense breasts, as reported in October 2005 in the New England Journal of Medicine.'

Advantages of digital mammography:
Existing mammography equipment can be converted to 'digital' operation, which allows cost savings compared to integrated digital mammography systems.

See also Breast MRI.