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Idiosyncratic Reactions
Patents can unintended respond with an idiosyncratic reaction to the application of contrast media. Idiosyncratic reactions to contrast agents start usually within 20 minutes after injection and occur more frequently in patients 20 to 40 years old.
Idiosyncratic reactions may or may not be dependent on the amount of dose injected, the speed of injection, the mode of injection and the radiographic procedure.

The minor symptoms are self-limited and of short duration and include:
scattered urticaria, pruritus, rhinorrhea, nausea, vomiting, diaphoresis, coughing, and dizziness.
Patients with minor symptoms should be observed for the progression or evolution of more severe reaction, which requires treatment.
Intermediate symptoms include:
diffuse urticaria, headache, persistent vomiting, facial edema, laryngeal edema, mild bronchospasm or dyspnea, palpitations, tachycardia, or bradycardia; hypertension; and abdominal cramps.
Intermediate symptoms require treatment and should be observed for progression.
Severe reactions include life-threatening symptoms:
arrhythmias (ventricular tachycardia), hypotension, overt bronchospasm, laryngeal edema, pulmonary edema, seizures and syncope.
Severe reactions are life-threatening and treatment is urgent and mandatory to prevent death.

See also Adverse Reaction and Anaphylactoid Reaction.
Nonionic Dimer
A nonionic dimer consists of 2 joined nonionic monomers. Nonionic dimers are used as x-ray and CT contrast media.
Nonionic dimers have the lowest osmolarity. These contrast materials contain 6 iodine atoms for every 1 particle in solution (CM ratio=6). Modern CT techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast agents. Nonionic dimers have the highest viscosity, which limits the clinical usefulness. Examples of nonionic dimers are iotrolan (Isovist®) and iodixanol (Visipaque).

See also Contrast Agents.
Nuclear Fission
Fissile isotopes such as 233U, 235U or 239Pu get exposed to a thermal neutron beam. The resulting nuclear chain reaction is controlled by moderators such as graphite, Beryllium or heavy water.
For example Mo-99, source for Tc-99m, is produced by fission of highly enriched uranium (HEU) in a few reactors around the world (monitored and controlled by The International Atomic Energy Agency).
Xeromammography
Xeromammography or xeroradiography is a breast imaging. Xeroradiography uses photoelectric records of x-ray images on a coated metal plate. Xeromammography as distinct from film-screen mammography uses low-energy photon beams, long exposure times and dry chemical developers.
Although xeromammography has sensitivity and specificity comparable with those of a film-screen mammogram, it is not recommended for screening or diagnostic mammography because of maintenance problems and the need for higher breast radiation doses compared with modern low dose mammography equipment.
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 [last update: 2023-11-06 02:01:00]