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Omnipaque
 
Omnipaque is a low-osmolar, nonionic, contrast medium with a broad range of indications, for example intravascular diagnostic procedures such as coronary angiography, spinal cord imaging, and body cavity procedures including shoulder and knee joints. Omnipaque is approved for use in adults and children, and is available in a wide variety of packagings.
See also Nonionic Contrast Agents.

Drug Information and Specification
NAME OF COMPOUND Iohexol
DEVELOPER GE Healthcare
INDICATION Brain and body computed tomography, urography, angiography
APPLICATION Intravascular
PHARMACOKINETIC Renal excretion
CHEMICAL BOND Nonionic monomer
OSMOLALITY 520, 672, 844 mosm/kgH2O
IODINE CONCENTRATION 240, 300 or 350 mg iodine
DOSAGE 50 to 250 mL depending on concentration and examination
PREPARATION Ready-to-use product
STORAGE Store below 30°Celsius (86°Fahrenheit)
PRESENTATION 50, 75, 100, 125, 150, 200 or 250mL bottle or +PLUSPAK (polymer bottle)
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
 
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• Related Searches:
    • GE Healthcare
    • Safety of Contrast Agents
    • Nonionic Contrast Agents
    • Contrast Enhanced Computed Tomography
    • Omnipaque for Oral Use


  Further Reading:
  Basics:
Omnipaque? Package Insert(.pdf)Open this link in a new window
by www.amershamhealth-us.com    
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Omnipaque for Oral Use
 
Omnipaque (iohexol) is a nonionic, low-osmolar contrast agent and is also available for oral use, offering gastrointestinal (GI) visualization with minimal side effects. Omnipaque has a neutral taste that even kids will drink.
Orally administered iohexol is poorly absorbed from the normal gastrointestinal tract. Omnipaque is well tolerated and absorbed if leakage into the peritoneal cavity occurs.
The recommended dosage of undiluted Omnipaque (at a concentration of for example 350 mg/mL) for computed tomography of the abdomen in adults is 500 mL to 1000 mL, diluted to concentrations of 6 mg/mL to 9 mg/mL. The oral dose should be administered about 20 to 40 minutes prior to the CT scan.

Drug Information and Specification
NAME OF COMPOUND Iohexol
MANUFACTURER GE Healthcare
INDICATION Bowel opacification
APPLICATION Oral, rectal
CONCENTRATION 140, 240, 300 or 350 mg iodine
DOSAGE 500 - 1000 mL of diluted solution
PREPARATION Ready-to-use product, dilutable
STORAGE Protect vials and glass or polymer bottles from strong daylight and direct exposure to sunlight. Do not freeze. Storage at controlled room temperature, 20°-25°C (68°- 77°F);
PRESENTATION 50, 75, 100, 125, 150, 200 or 250mL bottle or +PLUSPAK (polymer bottle)
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!


  Further Reading:
  Basics:
Omnipaque? Package Insert(.pdf)Open this link in a new window
by www.amershamhealth-us.com    
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GE Healthcare
 
www.gehealthcare.com

GE Healthcare is the result of the merger between GE Medical and Amersham Health in Nov. 2004, after GE acquired Amersham Health for 9.5 billion in Oct. 2003. Jeffrey R. Immelt, Chairman of the Board and Chief Executive of General Electric, said, 'Amersham's diagnostic pharmaceutical and life sciences business will add new, high growth platforms to GE Medical's diagnostic imaging, services and health care information technology businesses'. GE Healthcare, a UK company, is a unit of General Electric (NYSE: GE). GE Healthcare is a global leader in medical imaging, diagnostic imaging agents, interventional procedures, health care services, and information technology. For more than 100 years, health care providers have relied on GE Medical Systems, now GE Healthcare, for high quality medical technology and productivity solutions. GE Healthcare, headquartered now at the formerly seat of Amersham Healthcare in Great Britain, operates facilities around the world. Global Operations include organizations on the Americas, Europe, and Asia, including India, Japan, Korea China, Thailand and Vietnam.

Related Product Lines:
CT Systems:
LightSpeed VCT™ LightSpeed Pro™
LightSpeed RT™ LightSpeed Xtra™
BrightSpeed™ HiSpeed™

Contrast Agents:
TRADE NAME FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Omnipaque
Omnipaque for Oral Use
Visipaque
Hypaque Meglumine
Hypaque Sodium
Hypaque 76

Contact Information:
ONLINE www.gehealthcare.com
CONTACT INFO PAGE www.gehealthcare.com/contact

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Nonionic Monomer
 
Nonionic monomers are used as x-ray contrast agents. To create a nonionic monomer, the tri-iodinated benzene ring is made water soluble by the addition of hydrophilic hydroxyl groups to organic side chains (CM ratio=3). Nonionic monomers have an intermediate osmolarity, intermediate viscosity and elevated hydrophilicity with three atoms of iodine per molecule. Lacking a carboxyl group, nonionic monomers do not ionize in solution. A nonionic monomer is potentially less chemotoxic than an ionic monomer.
Common nonionic monomers are iohexol (Omnipaque), iopamidol (Isovue®), ioversol (Optiray®), and iopromide (Ultravist®). Nonionic monomers are contrast agents with a wide range of indications due to their nonionic nature and lower osmolalities.
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