Imaging refers to the visual representation of an object. Today, diagnostic imaging uses radiology and other techniques, mostly noninvasive, to create pictures of the human body. Diagnostic radiography studies the anatomy and physiology to diagnose an array of medical conditions. The history of medical diagnostic imaging is in many ways the history of radiology. Many imaging techniques also have scientific and industrial applications. Diagnostic imaging in its widest sense is part of biological science and may include medical photography, microscopy and techniques which are not primarily designed to produce images (e.g., electroencephalography and magnetoencephalography).
Brief overview about important developments:
Imaging used for medical purposes, began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette.
In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This diagnostic imaging technology allows information of biologic processes in vivo. Today, single photon emission computed tomography (SPECT) and positron emission tomography (PET) play an important role in both clinical research and diagnosis of biochemical and physiologic processes.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasound has been imported into practically every area of medicine as an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast imaging, real-time 3D or 4D ultrasound, and molecular imaging. The earliest use of ultrasound contrast agents (USCA) was in 1968.
The introduction of computed tomography (CT/CAT) in the 1970s revolutionized medical imaging with cross sectional images of the human body and high contrast between different types of soft tissues. These developments were made possible by analog to digital converters and computers. First, spiral CT (also called helical), then multislice CT (or multi-detector row CT) technology expanded the clinical applications dramatically.
The first magnetic resonance imaging (MRI) devices were tested on clinical patients in 1980. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.

Today, imaging in medicine has been developed to a stage that was inconceivable a century ago, with growing modalities:
x-ray projection imaging, including conventional radiography and digital radiography;
All these types of scans are an integral part of modern healthcare. Usually, a radiologist interprets the images. Most clinical studies are acquired by a radiographer or radiologic technologist. In filmless, digital radiology departments all images are acquired and stored on computers. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in a picture archiving and communication system (PACS). In telemedicine, medical images of MRI scans, x-ray examinations, CT scans and ultrasound pictures are transmitted in real time.

See also Interventional Radiology, Image Quality and CT Scanner.

(EMR) Electromagnetic radiation consists of an electric and a magnetic field component. All EMR travels in a vacuum at the speed of light. EMR is classified related to the frequency//length of the wave.
An EM wave consists of discrete packets of energy, named photons (quantization). The energy of the photons depends on the frequency of the wave. Planck-Einstein equation:
E = h * f
E (energy); h (Planck's constant); f (frequency)
EMR types include in order of increasing frequency//decreasing wavelength: radio waves, microwaves, infrared radiation, visible light, ultraviolet radiation, x-rays and gamma rays. EMR contains energy and momentum, which may be imparted when it interacts with matter.

See Gamma Radiation.

X-rays contain a range of energies (polychromatic photons), the higher energies pass through the patient, the lower energies are absorbed or scattered by the body. Ideally, the x-ray beam should be monochromatic or composed of photons having the same energy. Strong filtration of the beam results in more uniformity. The more uniform the beam, the more accurate the attenuation values or CT numbers are for the scanned anatomical region.
There are two types of filtration utilized in CT:
Inherent tube filtration and filters made of aluminum or Teflon are utilized to shape the beam intensity by filtering out the undesirable x-rays with low energy. Filtration of the x-ray beam is usually done by the manufacturer prior to installation. The half value layer provides information about the energy characteristics of the x-ray beam. Too much filtration produces a loss of contrast in the x-ray image.
A mathematical filter such as a bone or soft tissue algorithm is included into the CT reconstruction process to enhance resolution of a particular anatomical region of interest.

(MPI) The myocardial perfusion scan is the most common nuclear medicine procedure in cardiac imaging and allows assessing the blood-flow patterns to the heart muscles. The comparison of the radiopharmaceutical distribution after stress and at rest provides information on myocardial viability and cardiac perfusion abnormalities. ECG-gated myocardial perfusion imaging allows the assessment of global and regional myocardial function such as wall motion abnormalities.
The diagnostic accuracy of myocardial perfusion scintigraphy (also abbreviated MPS) allows reliable risk stratification and guides the selection of patients for further interventions, such as revascularization. MPI also has particular advantages over alternative techniques in the management of a number of patient subgroups, including women, the elderly, and those with diabetes. The use of this type of cardiac scintigraphy is associated with greater cost effectiveness of treatment, in terms of life-years saved, particularly in these special patient groups.
Myocardial perfusion scintigrams are acquired with a gamma camera. Single photon emission computed tomography (SPECT) is preferred over planar imaging because of the three dimensional nature of the images and their superior contrast resolution.
Common MPI radiopharmaceuticals, approved by the U.S. Food and Drug Administration (FDA) include: Tl-201 and the Tc-99m-labeled radiopharmaceuticals, such as sestamibi, tetrofosmin, and teboroxime for single-photon imaging. Rb-82 is used for positron emission tomography (PET) imaging.

See also Gated Blood Pool Scintigraphy, Myocardial Late Enhancement, Cardiac MRI and Echocardiography.

[Rest Mass Energy] The term refers to the concept of mass-energy equivalence. Einstein proposed that the equivalence of mass and energy is a general principle.
E=mc²
E = energy,
m = mass,
c = the speed of light in a vacuum.
c² is the conversion factor required to convert from units of mass to units of energy.
The rest energy of an electron or a positron for example amounts to 0.511 MeV.

See also Photon, Photon Energy.