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Mammography
Mammography is a diagnostic imaging procedure of the breast to detect and evaluate breast disease. Mammography is widely used as a screening method and plays a key role in early breast cancer detection.
The screening mammography is used to detect breast changes in women who have no signs or symptoms or noticed breast abnormalities. The goal is to detect a breast tumor before any clinical signs are observable.
A diagnostic mammography is used to investigate suspicious breast changes, such as a breast lump, an unusual skin appearance, breast pain, nipple thickening or nipple discharge.
A breast screening or standard mammography requires two mammograms from different angles of each breast including craniocaudal view and mediolateral view. Additional images can be made from other angles or focus on microcalcifications or other suspicious areas.
A mammogram is created by special mammography equipment with long wavelength of the used x-rays. Film-screen mammography is still the most widely used technology, but the state of the art technique is digital mammography. Conventional x-ray equipment was used to produce mammograms until dedicated mammography equipment became available in the late 1960s. Film-screen mammography and xeromammography, introduced in the early 1970s, used lower radiation doses and produced sharper mammograms. The second generation of mammography systems has been introduced in the early 1980s. Chief disadvantages of analog mammography include the labor-intensive handling of the cassettes, relatively slow processing time, the lack of a direct interface to the x-ray system, and no post processing possibilities.
Mammograms of high quality should be done with the lowest radiation dose as possible. Adequate breast compression is important due to shortening of the exposure times, immobilization of the breast, reduction of motion and blurring and prevention of overpenetration by means of equalizing breast thickness.
Further breast imaging procedures include breast ultrasound and breast MRI.
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Near Field
The near field is one of the boundary regions to classify characteristics of electromagnetic fields as a function of distance from the radiating source. The variation of the electromagnetic wave is usually more rapid in the near field than in the far field.
Neutron Activation Analysis
(NAA) Neutron activation analysis is a very sensitive analytical technique to determine even very low concentration of chemical elements, trace elements for example, in small biological samples.
NAA becomes commercial available in the USA in 1960.
In the activation process stable nuclides in the sample, which is placed in a neutron beam (neutron flux, 90-95% are thermal neutron with low energy levels under 0.5 eV), will change to radioactive nuclides through neutron capture (artificial radioactivity). These radioactive nuclides decay by emitting alpha-, beta-particles and gamma-rays with a unique half-life. Qualitative and quantitative analysis of the sample is done with a high-resolution gamma-ray spectrometer.
NAA is subdivided into the following techniques:
Fast NAA (FNAA): about 5% of the total flux consists of fast neutrons (energy above 0.5 MeV). As a consequence the radiation contains more nuclear particles.
Prompt Gamma NAA (PGNAA): gamma rays are measured during neutron activation. For detection of elements with a rapid decay.
Delayed Gamma NAA (DGNAA): conventional detection after the neutron activation.
Epithermal NAA (ENAA): ~ 2% of the total neutron flux with an energy level between 0.5 eV and 0.5 MeV are detected inside a cadmium or boron shield.
Instrumental NAA (INAA): automated from sample handling to data processing. Analyzes simultaneously more than thirty elements in most samples without chemical processing.
Radiochemical NAA (RNAA): After neutron activation the sample is chemically refined for better analysis.
Osmole
(Osm) A unit of osmotic pressure used in physical chemistry, cell biology, and medicine.
Definition: 1 osmole is the osmotic pressure of a one molar solution (that is, a solution with a concentration of one mole per liter of solvent) of a substance that does not dissociate.
If chemical solutions are separated by a semipermeable membrane (a membrane that resists the passage of dissolved substances but permits the passage of the solvent, usually water), then the solvent will diffuse across the membrane to equalize the concentrations. This process is called osmosis.
Solutions with higher concentrations of dissolved substances are said to have higher osmotic pressure than solutions having lower concentrations; thus the solvent moves from an area of low osmotic pressure to an area of higher osmotic pressure.
Osmotic pressure depends on the total number of dissolved particles, so for a substance that dissociates into two ions, such as ordinary salt (sodium chloride), a one molar solution has an osmotic pressure of 2 osmoles. In practice, most measurements are in milliosmoles (mOsm). Typical values range from 20 mOsm for fresh water through 290 mOsm for typical human blood plasma to 1010 mOsm for salt water from the open ocean.
See also Part Per Million.
Air Kerma
Air KERMA (Kinetic Energy Released per unit MAss of air) measures the amount of radiation energy in air, unit is J/kg. This include the initial kinetic energy of the primary ionizing particles such as photoelectrons, Compton electrons, positron//negatron pairs from photon radiation, and scattered nuclei from fast neutrons, when for example air is irradiated by an x-ray beam. J/kg (gray) is also the unit of the radiation quantity 'Absorbed Dose'.
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