The company is developing and making specialized medicines for treating multiple sclerosis, dermatological disorders, female health concerns, cancer and is creating new diagnostic imaging techniques. Berlex, Inc. is a pioneer in the imaging market. It has introduced a broad range of imaging agents. Its contribution began in 1988 with the introduction of the world's first magnetic resonance imaging agent, Magnevist® (gadopentetate dimeglumine) injection. Berlex is headquartered in New Jersey and the U.S. affiliate of Bayer Schering Pharma AG, Germany.

A biopsy is a procedure in which tissue samples are collected. This can be done with a needle, which is inserted into the abnormal area.
An example is the needle breast biopsy. Needle biopsies are usually guided by different imaging techniques like ultrasound, computed tomography, or magnetic resonance imaging. Stereotactic-assisted breast biopsies use computer maps to guide the needle. The location of the breast lump is provided from digital mammograms taken from two angles.
The cells can be removed and examined under a microscope to determine whether the abnormality is cancerous.

See also CT Guided Biopsy.

When a group of spins is placed in a magnetic field, each spin aligns in one of the two possible orientations. The relative numbers of spins with different alignments will be given by the Boltzmann distribution.
Definition: if a system of particles, which are able to exchange energy in collisions is in thermal equilibrium, then the relative number (population) of particles, N1 and N2, in two particular energy levels with corresponding energies, E1 and E2, is given by N1/N2 = exp [-(E1 - E2)/kT ] where k is the Boltzmann constant and T is the absolute temperature. For example, in NMR of protons at room temperature in a magnetic field of 0.25 tesla, the difference in relative numbers of spins aligned with the magnetic field and against the field is about one part in a million; the small excess of nuclei in the lower energy state is the basis of the net magnetization and the resonance phenomenon.

Breast imaging methods include mammography (mammogram), ultrasound, breast MRI, positron emission tomography, xeromammography, diaphanography and thermography.
Mammography is widely used as a screening method and diagnostic tool for breast cancer detection or evaluation of breast disease. Digital mammography takes multiple thin digital image 'slices' through the breast, which provides higher potential to see a small mass within dense tissue. The mammography quality standards act guarantees a high image quality.
Breast ultrasound (also called ultrasonography) should only be used as an additional imaging modality to evaluate specific breast abnormalities, especially to differentiate cystic from solid masses. Ultrasound is also used to guide needle breast biopsies.
Magnetic resonance imaging (MRI) is useful for breast MRI screening in cases of high cancer risk. In addition, multifocal breast cancer can be missed by standard practice mammography and can be early detected with breast MRI.

(CTA) A computed tomographic angiography or computerized tomography angiogram is a diagnostic imaging test that combines conventional CT technique with that of traditional angiography to create images of the blood vessels in the body - from brain vessels to arteries of the lungs, kidneys, arms and legs.
High resolution CT scans with thin slices and intravenous injection of iodinated contrast material provide detailed images of vascular anatomy and the adjacent bony structures. CTA requires rapid scanning as the imaging data are typically acquired during the first pass of a bolus of contrast medium. The selection of acquisition timing is important to optimize the contrast enhancement, which is dependent on contrast injection methods, imaging techniques and patient variations in weight, age and health. CT angiography is less invasive compared to conventional angiography and the data can be rendered in three dimensions.

CTA techniques are commonly used to:
See also Cardiovascular Imaging, Magnetic Resonance Angiography MRA, Coronary Angiogram, Computed Tomography Dose Index and Computed or Computerized Axial Tomography.