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Diagnostic Imaging
Imaging refers to the visual representation of an object. Today, diagnostic imaging uses radiology and other techniques, mostly noninvasive, to create pictures of the human body. Diagnostic radiography studies the anatomy and physiology to diagnose an array of medical conditions. The history of medical diagnostic imaging is in many ways the history of radiology. Many imaging techniques also have scientific and industrial applications. Diagnostic imaging in its widest sense is part of biological science and may include medical photography, microscopy and techniques which are not primarily designed to produce images (e.g., electroencephalography and magnetoencephalography).
Brief overview about important developments:
Imaging used for medical purposes, began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette.
In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This diagnostic imaging technology allows information of biologic processes in vivo. Today, single photon emission computed tomography (SPECT) and positron emission tomography (PET) play an important role in both clinical research and diagnosis of biochemical and physiologic processes.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasound has been imported into practically every area of medicine as an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast imaging, real-time 3D or 4D ultrasound, and molecular imaging. The earliest use of ultrasound contrast agents (USCA) was in 1968.
The introduction of computed tomography (CT/CAT) in the 1970s revolutionized medical imaging with cross sectional images of the human body and high contrast between different types of soft tissues. These developments were made possible by analog to digital converters and computers. First, spiral CT (also called helical), then multislice CT (or multi-detector row CT) technology expanded the clinical applications dramatically.
The first magnetic resonance imaging (MRI) devices were tested on clinical patients in 1980. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.

Today, imaging in medicine has been developed to a stage that was inconceivable a century ago, with growing modalities:
x-ray projection imaging, including conventional radiography and digital radiography;
scintigraphy;
single photon emission computed tomography;
positron emission tomography.

All these types of scans are an integral part of modern healthcare. Usually, a radiologist interprets the images. Most clinical studies are acquired by a radiographer or radiologic technologist. In filmless, digital radiology departments all images are acquired and stored on computers. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in a picture archiving and communication system (PACS). In telemedicine, medical images of MRI scans, x-ray examinations, CT scans and ultrasound pictures are transmitted in real time.

See also Interventional Radiology, Image Quality and CT Scanner.
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Prepcat
Prepcat (brand name Lafayette) is a barium sulfate suspension for computed tomography examinations of the gastrointestinal (GI) tract. The dosage and application depend on the specific procedure.
UPPER G.I. OPACIFICATION: The patient should drink 300 mL of ready-to-use Prepcat approximately 2 hours before the CT scan and an additional 300 mL approximately 15 minutes prior to examination.
If rapid upper gastrointestinal tract transit is desired, administer the product chilled.
TOTAL BOWEL OPACIFICATION: The patient should drink 300 mL the night preceding the examination, 300 mL two hours prior to the examination and 300 mL approximately 15 minutes prior to examination.

Drug Information and Specification
NAME OF COMPOUND
Barium sulfate (BaSO4)
MANUFACTURER
Mallinckrodt, Inc.
INDICATION
Bowel opacification
APPLICATION
Oral, rectal
CONCENTRATION
1.5 w/w (w/v) barium sulfate USP
300-900 mL
PREPARATION
Ready-to-use product
STORAGE
Store between 15° and 30°C (59° and 86°F). Protect from freezing.
PRESENTATION
450 mL bottle
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
VoLumen®
VoLumen® is a low density barium sulfate contrast agent especially designed for MDCT (multi-detector row CT) and PET/CT exams to mark the bowel. Volumen is useful for CT studies of the small bowel and mesenteric vessels.
Positive oral contrast media may limit the delineation between soft bowel tissues and the lumen and may cause artifacts. Water or methyl-cellulose transits very rapidly and may limit bowel distention and soft tissue differentiation. Volumen, similar to water appears hypodense (low Hounsfield values) on CT scan and can be used in conjunction with IV contrast. VoLumen's low density formulation is well-suited for computed tomography enterography.

Drug Information and Specification
NAME OF COMPOUND
Barium sulfate (BaSO4)
DEVELOPER
INDICATION
Bowel opacification
APPLICATION
Oral, rectal
CONCENTRATION
0.1% w/v, 0.1% w/w barium sulfate suspension
900 mL
PREPARATION
Ready-to-use product
STORAGE
Store at room temperature
PRESENTATION
450 mL bottle
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
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